Early and Late Onset Side Effects of Photodynamic Therapy

Early and Late Onset Side Effects of Photodynamic Therapy

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Photodynamic Therapy (PDT) is a non-invasive treatment successfully used for neoplastic, inflammatory and infectious skin diseases.One of its strengths is represented by the high safety profile, even in elderly and/or immuno-depressed subjects.PDT, however, may induce early and late onset side effects.Erythema, pain, burns, edema, itching, desquamation, and pustular formation, often in association with each other, are frequently metabo 15-gauge finish nailer cordless observed in course of exposure to the light source and in the hours/days immediately after the therapy.

In particular, pain is a clinically relevant short-term complication that also reduces long-term patient satisfaction.Rare complications are wd6001fsyz urticaria, contact dermatitis at the site of application of the photosensitizer, and erosive pustular dermatosis.Debated is the relationship between PDT and carcinogenesis: the eruptive appearance of squamous cell carcinoma (SCC) in previously treated areas has been correlated to a condition of local and/or systemic immunosuppression or to the selection of PDT-resistant SCC.Here we review the literature, with particular emphasis to the pathogenic hypotheses underlying these observations.